République Française Inserm
Institut thématique Immunologie, inflammation, infectiologie et microbiologie

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Symposium ROAD to 2030 - November 17th, 2025

November 17th, 2025 
Amphithéâtre Buffon – Université Paris Cité
15 rue Hélène Brion – 75013 Paris

The annual symposium of the ROAD to 2030 Inserm network was held on November 17th, 2025 in Buffon amphithéâtre (Université Paris Cité - Paris 13).

By integrating cell biology, tissue engineering, advanced imaging, biomechanics and public health, the musculoskeletal community is uniting to reinvent how we prevent and treat rheumatism and musculoskeletal diseases. The ROAD to 2030 network invited participants to a one-day symposium which unites clinicians with biologists and epidemiologists and engineers to speed up discoveries that will revolutionize patient care by 2030.
The day was introduced by Didier Samuel, Chairman and CEO of Inserm. The symposium featured four visionary keynote speakers Franziska Denk (Wolfson Sensory, Pain and Regeneration Centre, King's Collège London, UK),  Sestina Falcone (Centre de recherche en myologie, Paris), Nicholas Fuggle (Centre for Developmental Origins of Health and Disease, University of Southampton, UK) and Jean-Philippe Pradère (RESTORE lab, Toulouse), who presented their recent discoveries about neuro-inflammation, musculoskeletal ageing, population health and mitochondrial metabolism.
Rapid-fire talk sessions and an interactive poster walk provided numerous chances to test ideas and spark collaborations and showcase the French community work. 


>>>> Download the final Program

>>>> Download the Poster Booklet

Organizing committee
Francis Berenbaum, Roland Chapurlat, Nathalie Grivel, Jérôme Guicheux, David Moulin, France Pietri-Rouxel and Claire Vinatier

Program

8h45-9h15       Welcome coffee

9h15-9h25       Introduction - Didier Samuel, Chairman and CEO Inserm

9h25-10h45     Session1 Pain and inflammation in musculoskeletal disorders
                         Chairs: Alice Courties & David Moulin

9h30-10h10     Stromal cells – critical drivers of pain in arthritis? - Franziska DENK - King's College London (UK)

10h10-10h45    Selected talks

  1. A rare variant in the Extl3 gene is associated with altered Wnt signaling pathway in a novel mouse model of axial spondyloarthritis - Stéphane Hilliquin - UMR 1333 (Montrouge)
  2. Transcriptomic and epigenetic regulation of skeletal stem/progenitor cells during bone regeneration - Maria Ethel - UMR 955 (Créteil)
  3. Exposure To Endocrine Disruptors Exacerbates Osteoarthritic Pain And Inflammatory Responses In A Sex-Dependent Manner - Elise Herardot - UMR 938 (Paris)

10h45-11h00    Coffee break

11h00-11h10     Being patient in 2030 - Françoise Alliot Launois, President AFLAR

11h10-12h25    Session 2 Aging of the locomotor system
                          Chairs: Bénédicte Chazaud & France Pietri-Rouxel

11h10-11h50    Therapeutic landscape of strategies targeting age-related sarcopenia and the potential of GDF5-based treatments
                        Sestina Falcone - Centre de recherche en myologie (Paris)

11h50-12h25    Selected talks

  1. Characterisation of the role of ShcA as a new player in osteochondrogenesis - Zahida Hadidi - UMR 1109 (Strasbourg)
  2. Unveiling the role of the stromal factor Chi3L1 and its association with senescence in osteoarthritis - Georges Maroun - UMR 1183 (Montpellier)
  3. Study of the behavior of joint tissues and cartilage tissue-engineered products in contact with polydimethylsiloxane - Nicolas Potier - UMR 7365 (Nancy)

12h25-13h35    Time for a break? No not at all! Let’s move forward together!
                          Corné Baatenburg de Jong - Deputy Director ReumaNederland

12h35-13h30    Lunch break

13h30-13h50  European Calls - Cluster Health - Aude Raimbault, Inserm European Affairs Officer

13h50-14h00   Arthritis, empowering tomorrow’s scientific leaders - Lionel Comole, Chief Executive Fondation Arthritis

14h00-15h15    Session 3 Epidemiology: the burden of musculoskeletal disorders
                             Chairs: Roland Chapurlat & Francis Guillemin

14h00- 14h40 The developing epidemiology of musculoskeletal disorders - Nicholas Fuggle - University of Southampton (UK)

14h40-15h15    Selected talks

  1. Erosive Hand Osteoarthritis is Associated with Increased Risk of incident Osteoporotic Fractures in Post-Menopausal Women (QUALYOR Cohort) - Maxime Auroux - UMR 1033 (Lyon)
  2. Risk factors for structural progression of knee osteoarthritis: data from the KHOALA cohort - Augustin Latourte - UMR 1132 (Paris)
  3. Atopy is a comorbidity associated with osteoarthritis severity: results from the KHOALA COHORT - Kimberley Dolium - UMR 938 (Paris)

15h15-16h00    Posters and Coffee break

16h00-17h15    Session 4 Metabolism in musculoskeletal disorders
                          Chairs: Claudine Blin & Claire Vinatier

16h00-16h40    The mitochondria heterogeneity upon aging  - Jean-Philippe Pradère - RESTORE lab (Toulouse)

16h40-17h15     Selected talks

  1. Multimodal analysis of osteoarthritic chondrocytes reveals mitochondrial alterations and patient-specific OxPhos response to bezafibrate - Lucie Danet - UMR 1229 (Nantes)
  2. NLRP12 in osteoarthritis : a novel regulator of inflammation ? - Anaïs Julien - UR 7451 (Caen)
  3. Prolonged enzyme-mediated glucose delivery to support Mesenchymal Stromal Cell survival in ischemic environments - Samantha Magnin - UMR 1271 (Paris)

17h15-17h30    Conclusion

 

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